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Rhesus Factor – Rh Incompatibility

Description of Disease

There are essentially four types of major blood groups in humans – A, B, AB and O. The Rhesus factor is a substance in blood by which human blood may be divided by its presence into (Rh +ve) or (Rh -ve) groups. The final identification of a blood group is thus O +ve, B –ve etc.

There is some misconception that the same blood group in both partners may be detrimental. This is not true. The actual problem may occur when the mother is Rh –ve and the husband is Rh +ve irrespective of their ABO grouping.
The baby of such a union could be Rh –ve or Rh +ve. For an Rh –ve baby there will be no problems and no precautions need to be taken. For an Rh +ve baby on the other hand complications of varying severity may take place.


Reasons

Mixing of some blood of the baby and mother occurs throughout every pregnancy but more so at the time of delivery. The mixing of Rh +ve blood (from the baby) in a Rh -ve mother causes the mother to build up some negative factors (antibodies) in her blood over time against the Rh +ve blood cells. These negative factors may then cross over to the baby through the placenta (afterbirth) and destroy the blood cells of the baby. Usually the first pregnancy is spared, as a few months are needed for the negative factors to be built in the mother’s body. In the subsequent pregnancies Rh +ve babies are likely to be affected by the antibodies of the mother.


Symptoms


Tests may be done to estimate the amount of negative factors in the mothers’ blood. (Indirect Coombs’ test). This gives us an idea of the chances the baby may be affected. If the chances of the baby being affected are high – serial tests of amniotic fluid or blood directly from the baby in the womb are done. If the condition is mild, early delivery and treatment of the baby is done after birth. If severe, blood transfusions for the baby need to be carried out in the womb. These procedures are done in selected places by specialists and carry a high complication rate.

Precautions

Injections are given both during pregnancy and soon after delivery to prevent an Rh –ve mother carrying an Rh +ve baby from developing the negative factors. The same injection needs to be given after a miscarriage to neutralize the mixing of blood which occurs in those cases.


General Treatment


Treatment as explained above essentially depends on the severity of the condition. For severely affected babies, the chance of dying is high. Precautions include early identification of the high-risk pregnancies by checking blood groups with Rh factor for all pregnant women.

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Obstetric Cholestasis


Description of the disease

The term is used to describe jaundice like condition seen during pregnancy, usually in the last few months.

Reason

Cholestasis occurs due to the stagnation of bile in the gall bladder due to the action of hormones that are increased during pregnancy. The bile acids are not cleared adequately and the levels increase in the blood.


Symptoms

Itching all over the body, yellowing of the eyes, yellowish colored urine and pale stools are features of obstetric cholestasis.

Precautions

There are no ways of preventing the condition. It occurs more in the first pregnancy. An ultrasound is necessary to exclude stones in the gall bladder.

Treatment

Lotions applied over the areas of itching and anti histaminics help to relieve the itching. Careful supervision of the remaining pregnancy needs to be done, as complications of the baby are known to be associated with this condition. The baby needs to be given vitamin K injections soon after delivery.

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Stillbirth


Description of Disease


The term is used to describe the delivery of a dead baby or a baby who shows no signs of life after delivery.

Reasons

Though this could be due to both maternal and fetal (baby in the womb) causes, in up to 50% of cases no cause may be found. The maternal causes include diabetes and hypertension while fetal causes are growth restriction, congenital anomalies, cord accidents and distress (oxygen shortage) during or before the process of delivery. Stillbirths may occur secondary to a separating placenta or compression of the cord. (attaching baby to the placenta).

Symptoms

Inability of the mother to feel the baby kicks for a prolonged duration of time is the first hint that something may be wrong. On examination, the baby heartbeat is not heard. An ultrasound examination gives the final diagnosis.

Precautions

Some stillbirths cannot be prevented. Frequent check ups during the pregnancy period and diligent monitoring during the delivery process may help to prevent other stillbirths.

General Treatment

Delivery needs to be hastened after a stillbirth. Medicines to open the neck of the womb and make it contract are administered. Contrary to the popular belief, a delay in delivery of a dead baby by a few days does not usually cause any harm to the mother.


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Vasa Praevia


Description of disease

In this condition, blood vessels of the afterbirth (placenta) traverse through the membranes and occupy a position below the presenting part of the baby (usually head).


Reasons

There is no particular reason for this condition but identification by ultrasonography is helpful to avert a catastrophe.

Symptoms

In Vasa praevia, the blood comes directly from the baby and if not recognized early, the chances of the baby dying in the womb are very high. Bleeding starts as soon as the membranes rupture (breaking of waters). On gentle internal examination, pulsating vessels may be felt. The baby heart rate as recorded from the mother’s tummy shows signs of distress.

Precautions

Ultrasonography and Color Doppler studies can diagnose the condition. Internal examinations need to be avoided as they can lead to sudden heavy bleeding.


Treatment

Prompt recognition of the condition and delivery by cesarean section is the key and gives optimal results for the baby.


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Obstetric fistula


Description of the disease


A fistula is a connection within the body between two hollow organs – birth passage (vagina) and stool passage (rectum), birth passage (vagina) and urinary bladder etc.
When the fistula occurs as a result of a complication during the process of delivery it is called an obstetric fistula.

Reasons

A fistula between the vagina and urinary bladder may occur in cases of prolonged labor. This happens when the baby’s head gets stuck at the opening of the womb for a long time. A fistula between the vagina and the rectum may occur during the process of delivery when a cut near the opening of the birth passage gets extended.

Symptoms


A fistula with the urinary bladder causes continuous dribbling of urine through the vagina. This is associated with recurrent urinary tract infections and the continuous stench of urine. A fistula involving the rectum causes passing of stools, gas or foul smelling discharge through the vagina.

Precautions

Knowing the causes, appropriate obstetric management can prevent the occurrence of a fistula. In most cases the delivery is unsupervised or being performed by an inexperienced medical person.

Treatment

In almost all cases, the treatment is by surgery, which is usually done from the passage below.



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Oligohydramnios


Description of disease


This is a condition describing decreased water in the womb surrounding the baby.

Reasons


This could happen in a post-dated pregnancy i.e. when the expected date of delivery has been crossed. Leakage of fluid (PPROM) may also be responsible. It may also be seen along with anomalies of the baby especially involving the kidneys. Sometimes however no cause is found.

Symptoms

On clinical examination the height of the womb appears to be less than what is expected for that stage of pregnancy. A definite diagnosis is made on ultrasonography during which major anomalies of the baby are also ruled out.


Precautions


Regular check ups with the doctor during pregnancy help in early detection of the condition.

Treatment

Essentially depends on the reason for oligohydramnios. If pregnancy is prolonged, delivery needs to be planned. If the baby is severely deformed, pregnancy should be terminated. If there is leakage of fluid, early delivery or methods of fluid replacement need to be sought. If no cause is found, hydration therapy (drinking a lot of water) and amnioinfusion (injecting saline from outside) may be attempted. Frequent sonography examinations need to be done as a part of the follow up.


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Premenstrual syndrome


Description of the disease

This encompasses a list of physical and mental discomfort experienced by a woman for a few days usually prior to her periods. In almost all the cases the problems subside with the onset of periods.

Reasons

It is usually seen in women between the age group 20 to 40 years. Though the exact reason is not known, many believe that fluctuations in hormone levels are most likely to be responsible in susceptible women.

Symptoms

Symptoms include bloating, irritability, breast tenderness and a general feeling of unwell. Often the symptoms trouble women for a few months before subsiding on their own. They can recur from time to time.

Precautions

There are no ways of preventing the condition but treatment is indicated in women where the discomfort is severe enough to hamper normal activity.

General Treatment

Vitamin supplements and evening primrose oil are able to relieve symptoms in mild cases. For severe cases – hormones or other group of drugs may be necessary.


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Salpingitis


Description of the disease

This term refers to an infection of the fallopian tubes. Fallopian tubes are conduits on each side connecting the uterus (womb) and the ovaries (egg sac).


Reasons

The infection is often a sexually transmitted one, coming from an infected partner. Alternately tuberculosis may be a cause. Occasionally, these infections are seen after abortions or similar operations (D &C) from the birth passage.

Symptoms

In acute cases there is severe pain in the lower tummy, which may be associated with fever and nausea. In chronic cases, the pain may be long standing, increasing during periods. She may come to the doctor with infertility (the inability to bear a child). Sometimes there may be no problems at all and the diagnosis is made during a laparoscopy.

Salpingitis is seen frequently in women having multiple sexual partners. The usual age group is between 20 and 40 yrs.

Precautions

To prevent salpingitis – one needs to avoid intercourse with infected partners. The use of condoms by either the male or the female can help to reduce the incidence of this disease. Early diagnosis and treatment can help to prevent long-term complications. Three episodes of the disease can cause infertility in 50% of cases.

General Treatment

Treatment involves the use of antibiotics often for long durations. In severe cases medicines may need to be given by the intravenous route (directly in blood) for which patients require to be hospitalized. Often the damage done to the tubes by repeated infections is permanent and treatment does not reverse the damage.

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Trichomoniasis


Description of the disease


This is an infection of the birth passage (vagina) and the neck of the womb (cervix).
It is caused by a parasite, which is usually transmitted by intercourse with an infected partner.

Symptoms

Symptoms may include vaginal soreness, itching and a thick yellowish discharge.

Precautions

The disease is usually seen in the 15 – 30 year age group. It may be prevented by avoiding multiple or infected sexual partners. Barrier contraception in the form of condoms help to minimize the risk of transmission.

General Treatment


Testing the discharge for the parasites helps in the diagnosis. However, sometimes antibiotics are empirically administered. Usually problems settle in 1 – 2 weeks of starting treatment.

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Toxic shock syndrome


Description of the disease


This is a case of severe infection in the body by particular bacteria. It was seen first in women with infected tampons.

Reasons

The spread of organisms all over the body through the blood is responsible.

Symptoms

High-grade fever with chills and rigors. Rashes over the skin may be associated with the condition. In severe cases, the kidney may be affected.

Precautions

As forgotten pessaries are one of the common causes, careful note of the same needs to be taken.

Treatment

Urgent hospitalization and high dose antibiotics need to be administered.



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Uterine cancer


Description of the disease


Cancer refers to an abnormal growth, which may involve any part of the body. When the inner lining of the womb (uterus) is involved, the term uterine cancer is used.

Reasons

Though any woman can be affected, the condition is more commonly seen in obese and diabetic women. It is usually seen above 50 years of age, though rarely younger women may be affected.

Symptoms

Any irregular bleeding after the age of 40 needs evaluation. The bleeding may occur after the periods have stopped altogether (usually > 50 yrs) or in between two periods. Lower tummy pain or heaviness is uncommon.

Precautions


There are no ways of prevention of uterine cancer but early detection often leads to complete cure. Care needs to be taken for women on hormones after menopause.

General Treatment

Treatment is always by an operation where the uterus along with the tubes and ovaries are removed. In advanced cases however chemotherapy and radiotherapy may also be needed.


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Uterine Fibroids


Description of the disease

These are benign tumors arising from the womb (uterus). These fibroids are seen in 25 – 30 % of women after the age of 40 years.

Reasons
Symptoms

Often these tumors are incidentally detected on an ultrasound and do not produce any symptoms at all. Pain and bleeding during menstruation, lower tummy heaviness, problems during passing urine are other problems caused by the tumors. If the bleeding is very heavy – tiredness, lethargy and increased fatigability may be present due to anemia.

Precautions

Fibroids may occur in any age group but are most frequently seen between 30 to 50 years.

General Treatment


Treatment depends on the size and symptoms. Fibroids, which are large enough to be felt on the tummy, need to be removed surgically. If smaller in size and causing no problems they can be ignored. Surgery may involve removing just the tumor or the entire uterus. Removal of the entire womb (uterus) is considered when women have completed their child bearing or when they wish to preserve the uterus. For women who are unmarried or do not have any children – the tumors are removed only. The operation may be done by the usual cut on the lower tummy or by the laparoscopic (key hole surgery) route. Fibroids have a propensity to recur and many may be present at the same time.


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Uterine prolapse


Description of the disease

When the supports of the uterus (womb) become lax, the uterus tends to come down through the birth passage and protrude out during strenuous activity. In advanced cases it may be hanging outside while walking or standing up. Often part of the urinary bladder or rectum can also hang out with the uterus.

Reasons

Prolapse usually occurs due to the damage of the birth passage, which is incurred during the final stages of a normal delivery. Lack of hormones after menopause may worsen the process. Sometimes inherited defects in the muscles of the birth passage could be responsible.

Symptoms

Women with uterine prolapse usually complain of soreness and discomfort near the birth passage with the sensation of a mass coming down. The problem becomes more apparent while straining at stools. For chronic cases, ulcers may be present leading to a foul smelling discharge. Occasionally, there may be problems in passing urine with a feeling of obstruction. Prolapse is usually seen after the age of 50 years, though some degree may be seen soon after a normal delivery. Rarely, in young women due to inherited defects in the muscles, the same disease may be seen in early twenties.

Precautions


Prevention includes exercises of the muscles of the birth passage before and after a delivery. The use of hormones after menopause may be useful in some cases.

General Treatment

There is no medical treatment for uterine prolapse. Though exercises may be of benefit in mild cases, surgery is most often required. Surgery may be conservative where the lax supports are hitched up by an operation from the tummy above or the birth passage below. Radical surgery is appropriate for older women who have completed their family and involves removal of the uterus with correction of the deformity.

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Vaginal cancer


Description of the disease


This term refers to cancer occurring from the birth passage.
It is a rare form of cancer in women (1-2% of cancers) and presents usually after menopause.


Reasons

It could be due to chronic irritation due to uterine prolapse or a forgotten pessary.
Previous cancer from the mouth of the womb (cervix) or hysterectomy done in the past for cancer may be responsible.


Symptoms


Foul smelling discharge from the birth passage and bleeding on and off are the usual symptoms. Rarely pain may be present.


Precautions

Early treatment for uterine prolapse or any bleeding after menopause need sot be evaluated. Women known to have cancer in adjoining areas or having received treatment for the same in the past are susceptible.

General Treatment

Surgery can be done in early stages. Radiotherapy is the mainstay of treatment.. Survival rates of treatment depend on how early the disease is recognized.

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Vaginal Candidiasis


Description of the disease

This is a fungal infection involving the birth passage and is one of the most common abnormal causes of white discharge.

Reasons

It is very common and may be seen due to poor hygiene, overuse of antibiotics, uncontrolled diabetes and a variety of medical diseases.

Symptoms

White discharge is usually seen with varying degrees of soreness, discomfort and itching near or in the birth passage (vagina). There may be redness, burning and ulceration in the region as well. This is a disease that can be seen at any age group.

Precautions

Maintaining personal hygiene is the key. Frequent changing of sanitary napkins during periods and keeping the area dry is the key. Checking for diabetes and other immunodeficiency diseases need to be done.

General Treatment

Treatment is often single dose antifungal medicines and both sexual partners need to be treated for long-term relief. Sometimes creams or pessaries may be prescribed to apply locally. In recurrent cases treatment may be for be a prolonged period.

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Vaginitis


Description of the disease

The term is used to describe infection affecting the birth passage (vagina).

Reasons

The organisms causing infection may be acquired by the sexual route. Alternately, proximity to the urinary and bowel passages, make the vagina susceptible to infection. Often fungal infection or candidiasis is the cause.

Symptoms

Itching near the vagina, soreness and a discharge are the most common complaints. The discharge may be thick and foul smelling.

Precautions

Maintaining genital hygiene is important. Avoiding intercourse with infected partners or use condoms.

General Treatment

Treatment depends on the organism, which may be identified. Appropriate antibiotics need to be used for all sexual contacts to prevent recurrence.

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