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Gestational Diabetes

Description of Disease

This represents a state of abnormal glucose metabolism seen during pregnancy. It mimics diabetes but is first detected during pregnancy and usually after the seventh month.

Reasons


Though any pregnant woman may have gestational diabetes, it is usually seen in obese, elderly women and those with a family history of diabetes.

Symptoms


It is most often diagnosed by an oral glucose tolerance test at around seven months of pregnancy. In this test, a measured amount of glucose is taken by mouth and repeated blood tests are done over a 2-hour period. The condition usually causes no symptoms in the expectant mother. However, early detection of the disease is necessary as it can prevent pregnancy complications – early breaking of waters, preterm delivery and complications of the baby – larger than normal size, respiratory and metabolic problems at delivery.

Precautions


Testing for blood sugars in later months of pregnancy for high-risk women help in early detection of the condition and appropriate management.

General Treatment


Treatment depends on the levels of blood glucose. For mild cases, a diabetic diet is recommended which corrects the abnormality. For severe cases, insulin injections will be necessary. Generally oral medicines are not prescribed. Frequent checking of blood sugar levels is necessary after the detection of gestational diabetes. The baby in the womb needs to be monitored by serial ultrasound examinations.
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Post partum Hemorrhage


Description of Disease


This refers to a condition in which severe bleeding is encountered after the delivery of a pregnant woman. It could be after a normal delivery, instrumental delivery (forceps, vacuum etc) or after a cesarean section.

Reasons


There are several reasons for heavy bleeding. In up to 80% of cases, the muscular walls of the womb lose its contractility, become lax and are unable to compress the traversing blood vessels. Alternately, trauma to the womb or the birth passage could be responsible. Retained afterbirth and coagulation disorders are the other reasons for PPH. Women at greatest risk include - Multigravidas, those with over distended wombs, prolonged or induced labor, bleeding early in pregnancy and women who have been given epidural analgesia.

Symptoms

With heavy bleeding - pulse rate increases and blood pressure falls. This is a serious condition and needs urgent medical attention. There may be associated giddiness, fainting, confusion and black outs.

Precautions


PPH should be anticipated for every delivery, more so for high-risk cases. For prevention of PPH, drugs to contract the womb may be given in anticipation before the bleeding actually occurs. Massage of the womb through the tummy is another useful method for temporary control of bleeding.

General Treatment

Treatment of PPH starts with resuscitation of the woman. This means starting IV lines and administering fluids and blood. Stabilizing pulse and blood pressure is a priority along with identifying the cause of the bleeding and then arresting it. Tears in the passage need to be stitched up, while relaxed wombs need to be contracted by medicines. In exceptional cases when medicines do not work – surgical methods are resorted to. Removal of the uterus may be required as a life saving measure in some cases.

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HELLP Syndrome


Description of disease

The term is used to describe a serious clinical situation where high blood pressure in pregnancy is compounded with blood and liver disorders. This is a life threatening condition with a high chance of the baby being severely affected. Biochemical abnormalities seen in laboratory tests include elevated liver enzymes, a decreased clotting ability of the blood and ruptured blood cells.

Reasons


The cause for this disorder among pregnant women with high blood pressure is unknown.

Symptoms

Headache, nausea, blurring of vision and severe upper abdominal pain. The blood pressure is usually very high and there is loss of protein in the urine. Swelling of the body especially the legs is often seen.

Precautions

As the exact cause of the disease is unknown, methods to prevent it are not present.

General treatment


Treatment involves stabilizing the patient by reducing the blood pressure and correcting coagulation disorders at the earliest. Early delivery of the baby provides best results for both baby and the mother. Soon after delivery the condition almost always regresses in the mother, but it can recur (25% chance) in a subsequent pregnancy.

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Pain in pregnancy


Description of Disease


Painless, irregular contractions of the womb may cause varying degrees of discomfort in a woman throughout pregnancy. These pains are called Braxton-Hicks contractions.

Reasons

Though these innocent aches are the most common cause of pain in pregnancy, other possibilities like miscarriage, premature labor and premature separation of the placenta need to be considered. Infections of the stomach (gastritis), pancreas (pancreatitis), appendix (appendicitis), gall bladder (cholecystitis) and urinary bladder (cystitis) can also cause pain in pregnancy. Often simple ailments like flatulence or bloating, constipation and indigestion, which are common during pregnancy, may present as tummy pain in a pregnant women.

Symptoms

Pain usually starts in the low back or lower tummy and is of a cramping nature. It is most often transient. Persistent severe pain, associated with fever, vomiting or other localizing symptoms need urgent evaluation.

Precautions

It is important to know when to approach a doctor. In cases of doubt, it is always advisable to visit a doctor anyway.

General Treatment

Depending on the type of pain and severity, varying degrees of intervention may be necessary. Labor pains are typically intermittent with increasing intensity and frequency. Most often, the pain is mild, temporary and subsides on its own. Rarely, an anti spasmodic like drotaverine may be used to alleviate discomfort. Surgical intervention is required in exceptional cases only.


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Group B streptococci


Description of the disease

This refers to a type of bacteria, normally present in a woman’s body, which can infect a pregnant mother and have serious consequences in the baby.

Reasons

Normally these bacteria are present in the urinary tract and rectal areas and do not cause any disease. It is in some women during pregnancy, they creep into the birth passage and infect the membranes causing complications.

Symptoms

Usually no symptoms are seen in the mother. Yet, it may cause PPROM and preterm labor pains. In the baby, two types of illness can occur. Immediately after birth, a respiratory illness can develop causing breathing difficulty. A delayed illness seen after the first week can involve the brain and cause neurological problems.

Precautions

In high risk women screening for the bacteria can be done and appropriate antibiotics are then administered. The same antibiotics may be required during the time of delivery to prevent transmission to the baby.

Treatment

All women who are colonized with the bacteria do not get infected in pregnancy. Only a small number of pregnant women affected will transmit the bacteria to their babies. However, as the disease in the babies is a serious one and more so if born preterm, all women diagnosed with group B streptococci ought to receive appropriate antibiotics at the time of delivery.


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Placenta Praevia


Description of Disease


The word ‘placenta’ is used for the afterbirth, which carries blood and nutrients from the mother to the baby when it is in the womb. The placenta is normally positioned in the upper portion of the womb. When the placenta is situated in the lower part of the womb, partially or totally obstructing the birth passage, the term placenta previa or low lying placenta is used.

Reasons

This condition is seen in about 20% of women early in pregnancy (before 20 wks). As pregnancy advances, the afterbirth usually migrates to the upper part of the womb and the chance of the condition persisting at delivery is about 2 - 3%.

Symptoms

In this condition, there may be bleeding - mild to heavy at different stages of pregnancy, usually in the later months. In most cases however, the baby is not affected as the blood lost comes directly from the mother.


Precautions

There is no way to prevent the condition but early identification by ultrasonography is helpful. The woman is advised to limit her physical activity and avoid intercourse. Iron tablets, injections or blood transfusions are liberally used throughout pregnancy to boost the blood hemoglobin level in the mother. Hospitalization is advised as soon as any bleeding occurs. There are no medicines to stop the bleeding but in many cases it stops on its own.

General Treatment

Delivery by the abdominal route (cesarean section) is indicated when the placenta partially or totally obstructs the birth passage. Heavy bleeding, not responding to conservative treatment, requires a termination of pregnancy. Blood transfusion facilities should be available at the time of delivery.


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Placental Abruption


Description of Disease


Usually the afterbirth or placenta separates from the wall of the womb after the baby is delivered. When some degree of separation occurs when the baby is still in the womb the condition is called placental abruption.


Reason


Placental Abruption is a serious clinical condition. It may be seen in pregnant women with high blood pressure, after a sudden break of waters, in cases of multiple pregnancies or in women with other medical disorders. However, the condition is often unpredictable and presents as an emergency.

Symptoms


Abruption often presents as bleeding in the later part of pregnancy along with abdominal pain. On examination, the womb is tender and there is varying degrees of distress to the baby inside the womb. In the severe cases, the bleeding may be concealed i.e. occurs inside the tummy or more commonly in the wall of the womb. Severe compromise and often death of the baby occurs in severe cases of abruption. Maternal complications include heavy blood loss, clotting disorders and kidney dysfunction.

Precautions

General Treatment

Early suspicion and prompt diagnosis of the condition is the key to success. Delivery should be done in the fastest possible way. If the baby is alive a cesarean section is often the best mode of delivery especially when the neck of the womb is not open. As the chances of the baby being distressed are high, neonatologists need to be informed for looking after the baby immediately after the delivery. In conditions where the baby has already died in the womb, urgent delivery is still warranted keeping in view the maternal complications possible.

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Placental Insufficiency


Description of Disease


The afterbirth or placenta is the organ in the womb through which blood, oxygen and nutrients reach the baby from the mother. When the placenta fails to function properly, the baby is unable to grow optimally and the condition is called placental insufficiency.

Reasons

Placental insufficiency could arise from maternal diseases - high blood pressure, kidney problems, immunological disorders and other diseases affecting the blood vessels of the afterbirth. The same condition may arise if the afterbirth becomes too ‘old’ or the pregnancy goes much beyond the expected date of delivery.

Symptoms

Placental insufficiency may be suspected if the water is in the womb around the baby is reduced on examination or if the baby grow sub optimally. A more definite diagnosis is made by ultrasonography (often many) and Doppler studies. In the later, blood vessels of the placenta and baby are examined to detect reduced flow of blood.

Precautions

Early detection of the condition helps in assessing the time of delivery and minimizing the risks for the baby inside the womb.

General Treatment

Medical treatment of placental insufficiency has never been encouraging. A decision for early delivery, depending on the severity of the condition is usually made. The decision needs to be balanced against the risks of delivering a premature baby. Though normal delivery is not contraindicated, in severe cases of insufficiency cesarean section may be preferred.

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Post term pregnancy


Description of Disease

Normally the delivery date is calculated by adding nine months and seven days to the first day of the last menstrual period. This rule holds good for regular periods only. In cases where the periods are irregular or the date of the last period is unknown, an early ultrasound done in the first few months, can give a reliable guide to the delivery date. When the duration of pregnancy extends two weeks beyond the delivery date it is labeled as post term.

Reasons

Post term pregnancy may be seen in 3-10% of normal pregnancies. Before a diagnosis is made, the dates need to be checked and confirmed. It is seen more in women pregnant for the first time and in those with previous post term pregnancies.

Symptoms


Mothers and relatives are generally found to be quite anxious in post term pregnancies. The worries are of placental insufficiency and decreased water around the baby in the womb. While the former could lead to decreased supplies from the mother, the later may lead to choking in the womb.


Precautions

Regular visits to the doctor especially near the time of delivery can help in preventing complications due to postdates.

General Treatment

If there are no signs of compromise in the baby as assessed by ultrasound the options need to be discussed. Waiting may allow labor to set in on its own. If this does not happen or signs of compromise in the baby are seen, the patient needs to be hospitalized and medicines need to be administered to start labor pains.


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Postpartum depression


Description of Disease

Normally the delivery date is calculated by adding nine months and seven days to the first day of the last menstrual period. This rule holds good for regular periods only. In cases where the periods are irregular or the date of the last period is unknown, an early ultrasound done in the first few months, can give a reliable guide to the delivery date. When the duration of pregnancy extends two weeks beyond the delivery date it is labeled as post term.

Reasons

Post term pregnancy may be seen in 3-10% of normal pregnancies. Before a diagnosis is made, the dates need to be checked and confirmed. It is seen more in women pregnant for the first time and in those with previous post term pregnancies.

Symptoms


Mothers and relatives are generally found to be quite anxious in post term pregnancies. The worries are of placental insufficiency and decreased water around the baby in the womb. While the former could lead to decreased supplies from the mother, the later may lead to choking in the womb.


Precautions

Regular visits to the doctor especially near the time of delivery can help in preventing complications due to postdates.

General Treatment

If there are no signs of compromise in the baby as assessed by ultrasound the options need to be discussed. Waiting may allow labor to set in on its own. If this does not happen or signs of compromise in the baby are seen, the patient needs to be hospitalized and medicines need to be administered to start labor pains.


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Pre eclampsia


Description of Disease

This is a condition where raised blood pressure in pregnancy is usually combined with loss of protein in the urine. There is a varying degree of swelling in the body especially the legs. Though some swelling of the body is normal in pregnancy, when associated with high blood pressure, the woman needs evaluation. In extreme situations of high blood pressure, convulsions may be seen – a condition called eclampsia.

Reasons

The cause for pre eclampsia is essentially unknown. It is suggested that a vascular defect at the placental level may be responsible. Immuological and genetic factors could also contribute to pre eclampsia.


Symptoms

In cases of mild elevation of blood pressure the woman may not have any problems. In cases of severe elevation there may be headache, nausea, pain in the upper tummy and blurring of vision. The baby may be growth restricted especially if preeclampsia is long standing.

Precautions

Though there are few reports claiming the benefit of calcium and aspirin, more research on the subject is due.

General Treatment

Treatment depends on the severity of the hypertension, the time of pregnancy it was first detected and the condition of the baby. In severe cases, urgent delivery needs to be considered esp. if the baby is mature. Sometimes even if the baby is immature pregnancy needs to be terminated, keeping in mind the serious complications that may occur in the mother. For mild cases however, a more conservative approach may be justified. Medicines to lower blood pressure need to be administered to keep it to optimal levels. A close watch for signs of worsening hypertension needs to be sought as convulsions can occur in extreme cases.



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Preterm labor


Description of Disease

Any sign of labor seen before 37 completed weeks of pregnancy is called preterm labor. Contractions of the womb (pain lower abdomen) and the opening of the neck of the womb are signs of impending delivery. The risks mainly lie for the premature baby who may not yet be prepared for a life outside the mother’s womb. The extent of the risk depends on how early preterm labor sets in.

Reasons

Preterm labor, like many things in obstetrics, is generally unpredictable. However in certain subsets of women the risk is high - women experiencing preterm labor in earlier pregnancies, those with over distended wombs, infections in the birth passage and poor holding capacity of the neck of the womb.

Symptoms

Labor pains are classically described as being rhythmic and usually start in the lower back. They gradually increase in intensity, frequency and duration.

Precautions

At early stages of labor especially when the pregnancy is less than 34 weeks, medicines are administered to arrest the delivery process. In pregnancies which are greater than nine months in duration or when labor is in an advanced stage – delivery is allowed. Care needs to be taken of the newborn and intensive care treatment for preterm babies is often required. Difficulty in breathing, inability to feed initially and bleeding from the gut and brain are problems encountered in babies born too early. How the baby fares depends on how early the delivery has taken place and the efficiency of the baby care unit in the hospital.

General Treatment

Though cesarean section is often employed for delivering preterm babies, there is a lack of definite benefit in the practice.



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PPROM (Preterm premature rupture of membranes)


Description of Disease

Premature rupture of membranes refers to the breaking of waters before the onset of labor. ‘Preterm’ means the rupture occurs prior to 37 completed weeks of pregnancy.

Reasons

It often happens due to infection - the commonest cause. Other causes include secondary to the onset of delivery pains, over distended wombs (excess water or twins) and medical disorders complicating pregnancy. Sometimes, no cause may be found.

Symptoms


A sudden gush of fluid from the birth passage often without warning is the first evidence of PPROM. The leakage could be in small quantities where it may be mistaken initially for urine. Early identification is important as associated infections need to be treated and in some cases premature labor pains may start.

Precautions

Prevention strategies have been futile in most cases. Infections – urinary or genital tract if identified early need to be treated.


General Treatment

There is no way to stop the leaking of fluid. Treatment depends on when the leaking starts, how immature the baby is and presence of infections or medical problems in the mother. If membranes rupture very early in pregnancy – fifth or sixth month, a conservative approach is taken and often leaking stops on its own. Leaking after the completion of the eighth month however tilts the favor towards an early delivery. A short course of steroids is often prescribed to accelerate lung maturity in the preterm baby.




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Puerperal disorders


Description of the disease


This term applies to diseases occurring in a woman within the first six weeks of her delivery.

Reasons


Infections are most common of the puerperal disorders. They could affect the uterus (womb), breast, urinary bladder, lungs or the delivery wound. Breast problems include engorgement, localized collections of pus and cracked or sore nipples. Other puerperal disorders include bleeding and a variety of psychiatric problems.


Symptoms


Most infections present with fever and localizing signs. The cause of fever needs to be found out and treatment instituted. Breast pain could be due to infection, engorgement of milk due to inability to express or a localized collection of pus. Bleeding could be due to several factors and of varying amounts. Some mood changes are noticed in many women in the first week after a delivery. A close watch is essential to detect worsening.

Precautions

Plenty of oral fluids in the post delivery period are helpful in avoiding urinary infections. Breast-feeding should be monitored in the first few days to ensure correct methods are being used. Breasts need to be emptied after every feed. Nipples need to be cared for from the last three months of pregnancy.

Treatment

After identifying the cause of infection, appropriate treatment needs to be instituted. Hospitalization and the intravenous route for antibiotics may be needed in severe cases of sepsis. Otherwise outpatient treatment may suffice. Caution needs to be governed keeping in mind that most antibiotics are excreted in breast milk. Breast engorgement needs decompressing by a breast pump while localized pus collections need to be drained. Psychiatric problems need supportive treatment failing which medicines need to be started.

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